Activation of Bk-channels in Gh3 Cells by C-pla2-dependent G- Protein Signaling Pathway
نویسندگان
چکیده
Departments of Anesthesiology and Physiology and The Center for Cellular and Molecular Signaling Emory University School of Medicine Atlanta, Georgia, 30322 Address reprint requests to Dr. Donald D. Denson, Department of Anesthesiology, Emory University School of Medicine, 3B-South Emory University Hospital, 1364 Clifton Rd. Atlanta, GA 30322. Phone: (404) 778-3900 FAX: (404) 778-5194 Email: [email protected] Running Title: G-Protein Activation of BK-channels
منابع مشابه
Activation of BK channels in GH3 cells by a c-PLA2-dependent G-protein signaling pathway.
BK-channels in GH3 cells are activated by arachidonic acid produced by c-PLA2. beta-adrenergic agonists also activate BK channels and were presumed to do so via production of cAMP. We, however, show for the first time in GH3 cells that a beta-adrenergic agonist activates a pertussis-toxin-sensitive G protein that activates c-PLA2. The arachidonic acid produced by c-PLA2 then activates BK channe...
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Bradykinin (BK) or kallikreins activate B2 receptors (R) that couple Galpha(i) and Galpha(q) proteins to release arachidonic acid (AA) and elevate intracellular Ca2+ concentration ([Ca2+]i). Thrombin cleaves the protease-activated-receptor-1 (PAR1) that couples Galpha(i), Galpha(q), and Galpha(12/13) proteins. In Chinese hamster ovary cells stably transfected with human B2R, thrombin liberated ...
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تاریخ انتشار 2004